New Ray of Hope in Prognosis-Significance of Clinical, Histopathological and Biological Characteristics among Potentially Malignant Disorders and Oral Cancer– Case Series
G. Sathees Chandramouli *
Department of Oral Medicine and Radiology, Best Dental Science College, Tamil Nadu Dr. M. G. R Medical University, Ultra Nagar, Madurai-625104,Tamil Nadu, India.
CH. Uma Reddy
Department of Oral Medicine and Radiology, Best Dental Science College, Tamil Nadu Dr. M. G. R Medical University, Ultra Nagar, Madurai-625104,Tamil Nadu, India.
A. Steffina Lydia Jascinth
Department of Oral Medicine and Radiology, Best Dental Science College, Tamil Nadu Dr. M. G. R Medical University, Ultra Nagar, Madurai-625104,Tamil Nadu, India.
M. Anitha
Department of Oral Medicine and Radiology, Best Dental Science College, Tamil Nadu Dr. M. G. R Medical University, Ultra Nagar, Madurai-625104,Tamil Nadu, India.
B. R. Sathvikalakshmi
Department of Oral Medicine and Radiology, Best Dental Science College, Tamil Nadu Dr. M. G. R Medical University, Ultra Nagar, Madurai-625104,Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
Early detection of disease progression remains a challenging task mainly due to the lack of adequate early predictive markers. It is necessary to consider the biological behaviour and underlined molecular events while selecting treatment modalities in order to get the better outcome of oral potentially malignant disorders (OPMD) and oral cancer. The aim of the study was to evaluate Cytokeratin (CK) and vimentin expression in pre and post-treatment status of Oral leukoplakia, Oral sub mucous fibrosis (OSMF), Oral squamous cell carcinoma (OSCC) using Immunohistochemistry (IHC). These markers serve as prognostic indicators.
Keywords: Cytokeratins, vimentin, oral potentially malignant disorders.