Cephalosporin Resistant Pneumococcal Meningitis in a Child-A Case Report
Appiah-Korang Labi *
Department of Microbiology, Korle-Bu Teaching Hospital, P.O.Box 77, Accra, Ghana.
Joan Woode
Department of Child Health, Korle-Bu Teaching Hospital, P.O.Box 77, Accra, Ghana.
Nicholas T. K. D Dayie
Department of Medical Microbiology, School of Biomedical and Allied Sciences, College of Health Sciences, University of Ghana, P.O.Box KB 143, Accra, Ghana.
Eric S. Donkor
Department of Medical Microbiology, School of Biomedical and Allied Sciences, College of Health Sciences, University of Ghana, P.O.Box KB 143, Accra, Ghana.
*Author to whom correspondence should be addressed.
Abstract
Meningitis caused by Streptococcus pneumoniae is associated with severe morbidity and mortality. The occurrence of multi-drug resistant strains of S. pneumoniae is associated with treatment failure of pneumococcal infections. We present a case of multidrug resistant pneumococcal meningitis in a 10 month-old patient. The patient was admitted to the Department of Child Health of the Korle-Bu Teaching Hospital with high grade fever and irritability. She received an 8-day course of vancomycin after empirical treatment failure with ceftriaxone. Subsequently, she was discharged without complications on follow-up. Although resistance to ceftriaxone among Streptococcus pneumoniae in Ghana is rare, our report highlights an instance where an unusual ceftriaxone resistant isolate may be encountered as a cause of invasive disease leading to treatment failure.
Keywords: Streptococcus pneumoniae, vancomycin, ceftriaxone, meningitis, Ghana.