Massive Acute Hemolysis in Two Siblings with Glucose Dehydrogenase Deficiency and Parvovirus B19 Infection
Koji Yokoyama *
Department of Pediatrics, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.
Akira Yoshida
Department of Pediatrics, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.
*Author to whom correspondence should be addressed.
Abstract
Aims: A previous study reported hemolytic crisis in patients with erythro-enzymopathy. Here, we report two further cases of massive acute hemolysis with methemoglobinemia in two siblings with glucose dehydrogenase deficiency and parvovirus B19 (PAVB) infection.
Presentations of Case: The first was his 8-year-old brother, who developed mild hemolysis with liver dysfunction and survived. The second patient was a 10-year-old boy, who developed liver and kidney failure and died. To elucidate the mechanisms through which PAVB can cause liver and kidney failure, we analyzed cytokines and virus burden.
Conclusion: Physicians should be aware that severe hemolysis may occur in patients with hematological abnormalities and PAVB infection.
Keywords: Parvovirus B19, acute hemolysis, erythroenzymopathy, methemogulobinemia, household infection