Alkaline Diuresis as Treatment for 2, 4-D Dimethylamine Herbicide Intoxication: A Case Report
Nitesh Jindal *
Department of Medicine, SVSU, Meerut, Uttar Pradesh, India.
Tanu Raj Sirohi
Department of Medicine, SVSU, Meerut, Uttar Pradesh, India.
Patamsetti Anil Kumar
Department of Medicine, SVSU, Meerut, Uttar Pradesh, India.
Mohammad Shoeb
Department of Medicine, SVSU, Meerut, Uttar Pradesh, India.
Gali Shabarish
Department of Medicine, SVSU, Meerut, Uttar Pradesh, India.
Pediredla Sri Sowmya
Department of Medicine, SVSU, Meerut, Uttar Pradesh, India.
*Author to whom correspondence should be addressed.
Abstract
The use of 2, 4-D dimethylamine is expanding as a result of the rise in glyphosate and paraquat resistance in weeds [1]. Instances of 2,4D dimethylamine intoxication have been on the rise. This herbicide exhibits a range of dose-dependent harmful mechanisms, including cell membrane destruction, disruption of acetyl coenzyme A metabolism, and oxidative phosphorylation uncoupling [2]. The neurological system, heart, lungs, liver, muscles, and endocrine system may all be affected by toxic effects [3]. Results in male cases are fatal [2,4]. The usefulness of alkaline diuresis as a life-saving treatment for 2,4-D dimethylamine poisoning with severe symptoms is discussed in this paper. 2, 4-D dimethylamine intoxication can be fatal if not treated promptly. There is no particular antidote and alkaline diuresis shows good result in the patient who present with severe intoxication of 2, 4-D dimethylamine.
Keywords: Herbicide intoxication, 2, 4-D dimethylamine, alkaline dieresis, chlorphenoxy