Neurological Complications of COVID-19 Vaccination: A Case Report of Generalized Convulsive Status Epilepticus
Machlusil Husna
Division of Epilepsy, Department of Neurology, Faculty of Medicine, Universitas Brawijaya, Dr. Saiful Anwar General Hospital, Malang, Indonesia.
Ria Damayanti
Division of Epilepsy, Department of Neurology, Faculty of Medicine, Universitas Brawijaya, Dr. Saiful Anwar General Hospital, Malang, Indonesia.
Priyo Atdisuramad *
Department of Neurology, Faculty of Medicine, Universitas Brawijaya, Dr. Saiful Anwar General Hospital, Malang, Indonesia.
*Author to whom correspondence should be addressed.
Abstract
Generalized convulsive status epilepticus (GCSE) is a life-threatening condition characterized by prolonged seizure activity that affects both sides of the brain. Despite its high mortality rate, GCSE is a relatively rare complication of COVID-19 vaccination. In this case report, we presented a 28-year-old male with no known history of neuropsychiatric disorders who developed GCSE following the first dose of the mRNA COVID-19 vaccine. It is plausible that the COVID-19 vaccine played a role in the development of GCSE in this patient. This case report also provides brief review potential association between COVID-19 vaccination and GCSE. Enhanced post-vaccination monitoring protocols are essential for ensuring the safety of COVID-19 vaccination for patients with underlying medical conditions or those at heightened risk of neurological complications.
Keywords: Generalized Convulsive Status Epilepticus (GCSE), mRNA COVID-19 vaccine, COVID-19 vaccination