Mandibular Langerhans Cell Histiocytosis Presenting with Gingivitis: A Case Report and Literature Review
Yeşim Çağlar
*
Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Balıkesir University, Balıkesir, Turkiye.
Enes Dalmanoğlu
Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Balıkesir University, Balıkesir, Turkiye.
Berat Karaman
Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Balıkesir University, Balıkesir, Turkiye.
*Author to whom correspondence should be addressed.
Abstract
Langerhans cell histiocytosis (LCH) is a rare hematological disorder that may present in the oral cavity. Intraoral LCH lesions may present as masses, gingivitis, ulcers, gingival bleeding, tooth loss, pain, cysts, leukoplakia or non-healing wounds after surgery or tooth extraction. A multidisciplinary approach involving imaging, biopsy, and immunohistochemical analysis is essential for early diagnosis and management. This case underscores the diagnostic challenges and the importance of timely intervention.
This report presents a 47-year-old male with persistent mandibular pain and gingival inflammation which was initially considered to be complicated by osteomyelitis. Biopsy confirmed the diagnosis of LCH. The case highlights the importance of considering LCH in the differential diagnosis of atypical mandibular lesions in adults.
Keywords: Langerhans cell histiocytosis, mandible, gingivitis, osteomyelitis, oral pathology