International Journal of Medical and Pharmaceutical Case Reports

Background: Oral lipoma is an uncommon benign mesenchymal neoplasm composed of mature adipocytes. Its clinical appearance can overlap with other reactive and neoplastic oral soft-tissue lesions, making histopathological confirmation important.

Objective: To describe and compare the clinicopathological features of two conventional lipomas arising in the buccal mucosa.

Case Presentation: A 57-year-old woman presented with a painless, gradually enlarging yellowish swelling of the left posterior buccal mucosa for approximately one and a half months. A 71-year-old woman presented with a painless swelling near the left labial commissure that had enlarged over three months while retaining normal mucosal colour. Both lesions were well circumscribed and soft and were removed by complete surgical excision under local anaesthesia. The excised specimens measured approximately 0.6 × 0.5 cm and 0.5 × 0.5 cm, respectively. Histopathological examination showed lobules of mature adipocytes separated by delicate fibrous septa. The first lesion was well circumscribed but unencapsulated, whereas the second was enclosed by a thin fibrous capsule. No atypia, lipoblast formation, increased mitotic activity, or other evidence of malignancy was identified. Immediate postoperative healing was uneventful in both patients.

Conclusion: Conventional buccal mucosal lipomas may differ in mucosal colour and capsule status despite similar mature adipocytic morphology. Correlation of clinical findings with histopathological examination is essential for definitive diagnosis and appropriate management.