Spiradenoma: A Case Report with Evidence Reinforcing the Thickened Nerve Fibers in the Tumor Capsule
Selda Pelin Kartal *
Ministry of Health Ankara, Diskapı Yildirim Beyazit Education and Research Hospital, Dermatology Clinic, Turkey.
Mehmet Kocak
Ministry of Health Ankara, Diskapı Yildirim Beyazit Education and Research Hospital, Dermatology Clinic, Turkey.
Nimet Koklu
Ministry of Health Ankara, Diskapı Yildirim Beyazit Education and Research Hospital, Pathology Clinic, Turkey.
Ataturker Arikok
Ministry of Health Ankara, Diskapı Yildirim Beyazit Education and Research Hospital, Pathology Clinic, Turkey.
Cemile Altunel
Ministry of Health Ankara, Diskapı Yildirim Beyazit Education and Research Hospital, Dermatology Clinic, Turkey.
*Author to whom correspondence should be addressed.
Abstract
Aim: Spiradenoma is a rare tumor. Spontaneous pain and tenderness on palpation is a frequent symptom of the disease. Although the cause of pain in spiradenoma is not clarified yet, thickened nerve fibers in the capsule of tumor have been suggested to be related to the pain symptoms.
Case: We here report a woman with painful nodules on her abdomen for two months. The histopathological examination confirmed the diagnosis of spiradenoma. Immunohistochemically the tumor nodule and capsule were both S-100 positive, whereas the neuron specific enolase stained only the capsule of the tumor.
Discussion: Although further studies are required to explain the exact mechanism of pain in these tumors, by reporting this case, we provide additional evidence for the existence of thickened nerve fibers in the capsule of spiradenoma.
Keywords: Spiradenoma, painful skin tumor, nerve fibers, S-100, neuron specific enolase.