Bactrim-induced Severe Thrombocytopenia in Pregnancy
Shiwei Huang *
Department of Medicine, Drexel University School of Medicine, 2900 W Queen Ln, Philadelphia, PA, 19129, USA.
Robert Tenney
Department of Medicine, Drexel University School of Medicine, 2900 W Queen Ln, Philadelphia, PA, 19129, USA.
Muhammad Azharuddin
Department of Internal Medicine, Monmouth Medical Center, 300 2nd Ave, Long Branch, NJ, 07740, USA.
Mridul Gupta
Department of Internal Medicine, Monmouth Medical Center, 300 2nd Ave, Long Branch, NJ, 07740, USA.
Wael Ghali
Department of Internal Medicine, Monmouth Medical Center, 300 2nd Ave, Long Branch, NJ, 07740, USA.
*Author to whom correspondence should be addressed.
Abstract
A 29-year-old Caucasian woman at 30 weeks’ gestation presented with severe and asymptomatic thrombocytopenia with a platelet count of 17 × 109/L after completing 9 days out of a 10-day course of Bactrim DS for a nasal abscess. Upon further investigation, Bactrim-induced thrombocytopenia was diagnosed. After discontinuing this medication, her laboratory abnormalities immediately improved without any additional interventions.
Keywords: Drug-induced thrombocytopenia, Trimethoprim/sulfamethoxazole, steroids, platelet count, gynecology/obstetrics.